I just saw a severely fear aggressive dog today who has never had a truly thorough physical exam, even pre-med doses of medications still allowed him to be aware enough to be disturbed by the exam.
Today, the owner elected to try some alprazolam they had for thunderstorms, a high dose this time.
He was mildly sedated, and the dose was pretty high, but the fearful guy walked up to me wagging his tail instead of growling from across the room, and instead of trying to bite for vaccines, he was happily snarfing our soft treats.
I was able to diagnose a heart murmur, and its unclear if he had it before or not due to the amount of growling present in the past. Thanks to alprazolam, this dog may have a chance at early treatment.
Just needed to share my happiness at finally, after 9 years, allowing this scared dog to have a happy vet visit!