I have been researching the safety of giving Grape Seed extract to dogs. I could only locate one article....... However, I do know that grape seed extract is only from the seed of the grapes and the flesh is not used. It is typically a by product from wine makers
Courtesy of http://www.holisticpetinfo.com
Grape seed extract (GSE) (Vitis Vinnifera) is an extract from grape seeds from red grapes. Grape seeds have a high content of compounds called oligomeric proanthocyanidins— better known as OPCs, which are potent antioxidants. Because of their simple chemical structure, OPCs are readily absorbed into the bloodstream.
Grape seed extract:
* Protects the body from premature aging and disease
* Supports healthy skin
* Promotes cellular health, elasticity, and flexibility
* Improves blood circulation by strengthening capillaries, arteries, and veins
* Reduces risk of cataracts
* Protects against cancer
* Provides cardiovascular support
Grape seed extract is especially beneficial to aging animals, and animals with cataracts, cancer and heart disease.
On the Safety of Grape Seed Extract: Grapes and raisins have been of much debate in the past few years. Here is a short quote from the Veterinary Information Network board posts ”Ingestion of grapes or raisins has been associated with acute renal failure in dogs. Anecdotal evidence suggests that cats may also be affected… Being a fructose sugar, it is quickly eliminated through the kidneys where it reaches high tissue levels. It then causes a certain cell “power house” called the mitochondria to open and allow calcium to enter.” This causes the mitochondria to stop functioning, therefore the death of the cell. “Recent unpublished data indicates that the toxic component is water soluble, and within the flesh of the grape/raisin, not the seed. Thus the current thinking is that grape seed may be safe to use.”
Grape seed is often found with antioxidant supplements used for human cancer treatments. The seed induces the cell deaths of highly replicating cancer cells. There was a study done on men with prostate carcinoma which showed approximately 90% inhibition of the pathways that induces the growth of the cancer cells.
The flavanoids in the seed are known to reduce inflammation, and support the immune system particularly with respiratory issues, allergies, and skin problems. It has been used in cats and dogs successfully without any reported problems.