Kingsgurl wrote:How effective is the Levamisole against the adult worms? I know it kills off the microfilaria in the bloodstream, which would arrest the progression of the disease. The antibiotics kill of bacteria needed by the adults to reproduce, as well. Does the Levamisole slowly kill off the adults or is it similiar to the other slow kill method (preventative) in that it shortens their lifespan?
It is awesome your pup is doing so well. Scary, nasty things, heartworms! He looks so happy enjoying the sun!
Limited efficacy of levamisole against adults of Dirofilaria immitis in a dog
J Am Vet Med Assoc. June 1988;192(12):1743-4.
O O Barriga1; F Andujar
1Department of Veterinary Pathobiology, Ohio State University, Columbus 43210-1092.
A dog with chronic dirofilariasis (Dirofilaria immitis) was given 15 doses of 12 or 24 mg of levamisole/kg of body weight in 6 treatments within 96 days. Concentration of microfilariae in the blood was determined before and after treatment, and Aedes triseriatus mosquitoes were fed on the dog 1 to 5 days after each treatment and examined for D immitis larvae. Several adult worms were recovered from the dog 160 days after the end of the treatments.
LEVAMISOLE at 10 mg/kg PO sid for 7 days appears to be an effective microfilaricide. Adverse effects include vomiting, diarrhea, behavior changes, seizures, tremors, coma, hyperthermia, and depression. Crushing the bollets may increase toxicity. An adulticide dose of 11 mg/kg for 30 days gives inconsistent results and may cause hemolytic anemia, thrombocytopenia, arrhythmias, and reticuloendotheliosis of the CNS. Different formulations are available in the US and Australia and may account for the differences in results seen.
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