SAM-e - anyone giving it to their dogs?

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SAM-e - anyone giving it to their dogs?

Postby mtlu » Sat Aug 03, 2013 12:08 am

I'm wondering if anyone here is (or has) given their dogs SAM-e. In my beginning research of it, it seems to be mainly used for support of liver function but I'm seeing it recommended for arthritis support also.

Molly is in some early stage of developing arthritis - not a shock given her history of torn CCL's and repairs. The other things she is getting are Grizzly Pollack Oil; Vit E (alpha tocopherol succinate); Connectin (I have only recently started her on this product but it seems like a pretty good, comprehensive joint supplement with the usual glucosamine, chondroitin stuff in addition to yucca, hyaluronic acid, curcumin and some other stuff). Kefir, raw local honey and kelp are the other things that get added to her kibble.

If anyone is giving SAM-e to their dog(s), have you noticed any side effects? Benefits? Any other observable changes?
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Re: SAM-e - anyone giving it to their dogs?

Postby Misskiwi67 » Sat Aug 03, 2013 3:25 pm

Its amazing for liver support. I've not heard of its usefulness for arthritis.
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Re: SAM-e - anyone giving it to their dogs?

Postby Misskiwi67 » Sat Aug 03, 2013 3:29 pm

Found a couple articles from 2006. Seems legit - I wonder why its not more mainstream if this is real? Cost maybe?


Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis.

Hosea Blewett HJ.
Department of Agriculture, Food & Nutritional Sciences University of Alberta, Edmonton, AB. Heather.Hosea@afhe.ualberta.ca

Osteoarthritis is a chronic joint disease characterized by pain and immobility due to a gradual loss of cartilage. Current treatments are palliative; there is no cure. With a growing interest in alternative therapies, due in part to safety issues regarding pharmacological treatments like Celebrex, safe dietary compounds that help the body regenerate cartilage tissue are of great clinical importance. The dietary supplement S-adenosylmethionine (SAMe) shows such potential. Clinical trials have shown reduced pain and stiffness while in vitro and animal studies have shown SAMe can stimulate the production of cartilage which is critical in reversing the disease process. The author examines many potential mechanisms of action including: reduction of inflammatory mediators; increasing levels of glutathione; direct or indirect signaling of cartilage synthesis or survival; maintenance of DNA methylation. Research into the mechanisms of supplemental SAMe in osteoarthritis is necessary to evaluate the clinical effectiveness and safety of this dietary supplement.


Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and pharmacodynamics.Stramentinoli G.
BioResearch S.p.A., Research Laboratories, Milan, Italy.

Several studies in animals have shown the efficacy of parenteral S-adenosylmethionine (SAMe) as an anti-inflammatory drug. In this article, data are reported on plasma kinetics, distribution, and metabolism of SAMe after oral administration since preference is given to oral dosage in the usual clinical practice. The results demonstrate the intestinal absorption of SAMe and its active metabolism. Experiments confirm the anti-inflammatory activity of the drug by the oral route. Results are also reported on the analgesic effect of SAMe
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Re: SAM-e - anyone giving it to their dogs?

Postby mtlu » Sat Aug 03, 2013 9:03 pm

Misskiwi67 thanks for those articles. I've done a little bit more reading and it does sound like a wonder-supplement, used to also treat depression in addition to liver support and arthritis.

Quick question for you, are there effective non-opioid pain relievers available for dogs? Apparently, SAM-e can interact with opioids (and a few other things) and may lead to serotonin syndrome. My guess is that people taking higher doses of SAM-e to treat depression would be more at risk for this but I would like to be on the safe side if I try giving SAM-e to Molly. We keep metacam and tramadol on hand in case Molly seems to be experiencing any pain (she hasn't shown any pain since recovering fully from her TPLO plate removal but I feel better having both on hand). In the past, I would give her tramadol for immediate relief but now I would like to know if non-opiod pain relief options are available.
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Re: SAM-e - anyone giving it to their dogs?

Postby Misskiwi67 » Sun Aug 04, 2013 11:41 pm

mtlu wrote:Misskiwi67 thanks for those articles. I've done a little bit more reading and it does sound like a wonder-supplement, used to also treat depression in addition to liver support and arthritis.

Quick question for you, are there effective non-opioid pain relievers available for dogs? Apparently, SAM-e can interact with opioids (and a few other things) and may lead to serotonin syndrome. My guess is that people taking higher doses of SAM-e to treat depression would be more at risk for this but I would like to be on the safe side if I try giving SAM-e to Molly. We keep metacam and tramadol on hand in case Molly seems to be experiencing any pain (she hasn't shown any pain since recovering fully from her TPLO plate removal but I feel better having both on hand). In the past, I would give her tramadol for immediate relief but now I would like to know if non-opiod pain relief options are available.


Gabapentin is the only one I'm familiar with in dogs, and I use it more for bone/cancer pain, and occasionally severe acute abdominal pain with mixed results. How effective it would be for osteoarthritis I'm not sure, nor do I know if it would interact poorly with Sam-e.
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Re: SAM-e - anyone giving it to their dogs?

Postby mtlu » Mon Aug 05, 2013 10:43 pm

Thanks again, Misskiwi! I will be talking to at least two vets here also after I do some more research so hopefully I will get to a point where I can decide how to proceed. It's great that there are so many options with supplements but also so much additional research to do.
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Re: SAM-e - anyone giving it to their dogs?

Postby turtle » Sat Aug 24, 2013 2:00 pm

I’ve not been on line much, so I just saw this…

My dog has been on the SAMe (denosyl) for over a year now. She is on it because her liver numbers were scary high last year, something like 1900 when they should have been about 120. It has worked very well for lowering her liver numbers, it was gradual but they are now down to about 300 which still high but is far better than the 1900 they were a year ago.

I had not heard about SAMe being recommended for arthritis and joint pain. I am not sure how well it works for that as my old girl is 12 yrs old now and she has quite bad arthritis. She does get a joint supplement every day which has helped in the past, Liquid Health 5000, and salmon oil plus some yucca added to her food. She still limps and has trouble walking… but she is 12 yrs old with bad structure and she had cruciate surgery in 2009.

She gets the SAMe every day and I did not notice any side effects. It certainly has helped her liver function and I am interested that it is suggested for arthritis too.

Thank you Misskiwi67 for the articles and info! If you learn more, Mtlu, please post it!

Oh and when I buy the Denosyl, I usually buy it from Amazon. My vet charged me $105 for a month’s supply (30 pills) and Amazon is usually about $50.
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Re: SAM-e - anyone giving it to their dogs?

Postby mtlu » Sun Aug 25, 2013 11:14 am

turtle, thanks for replying! I have seen more info for SAM-e helping liver function than that of osteoarthritis but there does seem to be some info supporting evidence that it can help with arthritis if you google for SAM-e + arthritis.

Honestly, I'm still on the fence about it. It also has effects that are similar to SSRIs which alter how the body handles serotonin and that worries me a little bit. For Molly, since she is close to 7 yrs old right now, whatever I give her will be something she would take for quite some time and I have some concerns about monkeying with serotonin levels long term. It is difficult to find info about long term effects of SSRIs (since most research into SSRIs are geared towards big pharma anti-depressant drug industry but I have known a couple of people who have some lasting side effects from having taken Prozac) and I don't have biology/chemistry/neurochemistry background.

In the case of liver problems, obviously, the need to change and control levels over the short term far outweighs long term worries. Are you also supplementing with B vitamins (B6, B12, folate)? I've seen B vitamins mentioned in conjunction with SAM-e in quite a few articles.

Another concern is also the potential for interaction with tramadol which I posted about earlier in this thread.

I used to give Molly the Liquid Health 5000 but never saw much difference, to be honest. If it works for your girl, by all means continue - I think there's a lot of trial & error in finding what things work. One thing that the ortho specialist we saw mentioned was to find the fish oil with the highest EPA possible - supposedly the EPA omega fatty acids are best for joints/inflammation. That is why I went with the Grizzly Pollack Oil (same "Grizzly" company that makes the salmon oil).
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